US 11,814,650 B2
Method for expanding stemness and differentiation potential of pluripotent cells
Marcos Malumbres, Guadalix de la Sierra (ES); Maria Salazar-Roa, Madrid (ES); Marianna Trakala, Cambridge, MA (US); and Mónica Alvarez-Fernandez, Madrid (ES)
Assigned to FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III (F.S.P. CNIO), Madrid (ES)
Appl. No. 16/616,892
Filed by FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO), Madrid (ES)
PCT Filed May 25, 2018, PCT No. PCT/ES2018/063853
§ 371(c)(1), (2) Date Nov. 25, 2019,
PCT Pub. No. WO2018/215662, PCT Pub. Date Nov. 29, 2018.
Claims priority of application No. 17382304 (EP), filed on May 26, 2017.
Prior Publication US 2021/0147804 A1, May 20, 2021
Int. Cl. C12N 5/077 (2010.01); C12N 5/074 (2010.01)
CPC C12N 5/0657 (2013.01) [C12N 5/0696 (2013.01); C12N 2310/141 (2013.01); C12N 2501/235 (2013.01); C12N 2501/602 (2013.01); C12N 2501/603 (2013.01); C12N 2501/604 (2013.01); C12N 2501/605 (2013.01); C12N 2501/608 (2013.01); C12N 2501/65 (2013.01); C12N 2501/999 (2013.01); C12N 2506/02 (2013.01); C12N 2506/45 (2013.01)] 16 Claims
 
1. A method for dedifferentiating pluripotent stem cells to a more-naive state, which comprises:
culturing pluripotent cells and
exposing the pluripotent cells to miR-203 or an analogue thereof.