US 11,814,464 B2
Poly(amine-co-ester) polymers and polyplexes with modified end groups and methods of use thereof
W. Mark Saltzman, New Haven, CT (US); and Yuhang Jiang, New Haven, CT (US)
Assigned to YALE UNIVERSITY, New Haven, CT (US)
Filed by Yale University, New Haven, CT (US)
Filed on Apr. 29, 2020, as Appl. No. 16/862,491.
Claims priority of provisional application 62/840,220, filed on Apr. 29, 2019.
Prior Publication US 2020/0399424 A1, Dec. 24, 2020
Int. Cl. C08G 63/685 (2006.01); A61K 47/59 (2017.01)
CPC C08G 63/685 (2013.01) [A61K 47/595 (2017.08)] 27 Claims
 
1. A polymer of Formula I:

OG Complex Work Unit Chemistry
wherein n is an integer from 1-30, m, o, and p are independently integers from 1-20, x, y, and q are independently integers from 1-1000, Rx is hydrogen, substituted or unsubstituted alkyl, or substituted or unsubstituted aryl, or substituted or unsubstituted alkoxy, Z and Z′ are independently O or NR′, wherein R′ is hydrogen, substituted or unsubstituted alkyl, or substituted or unsubstituted aryl,
wherein R1 and R2 are chemical entities containing a hydroxyl group, a primary amine group, a secondary amine group, a tertiary amine group, or combinations thereof.