US 11,814,450 B2
Polymeric solid support for oligonucleotide synthesis
Jingshe Song, Union City, CA (US); John Michael Cue, Union City, CA (US); Yun-Chiao Yao, Union City, CA (US); David Yu, Union City, CA (US); and Aldrich N. K. Lau, Palo Alto, CA (US)
Assigned to Hongene Biotech Corporation, Union City, CA (US)
Filed by Hongene Biotech Corporation, Union City, CA (US)
Filed on Oct. 20, 2022, as Appl. No. 18/048,350.
Claims priority of provisional application 63/271,017, filed on Oct. 22, 2021.
Prior Publication US 2023/0130509 A1, Apr. 27, 2023
Int. Cl. C08F 12/32 (2006.01); C08F 2/08 (2006.01); C08F 12/22 (2006.01)
CPC C08F 12/32 (2013.01) [C08F 2/08 (2013.01); C08F 12/22 (2013.01)] 30 Claims
 
1. A polymer comprising one or more repeating units of Formulas (I), one or more repeating units of Formula (II), and one or more crosslinker repeating units of Formula (III), (IV), or (V), or combinations thereof:

OG Complex Work Unit Chemistry
wherein X is absent or C1-C4 alkylene;
R1 is —OH, —NH2, —OC(═O)Ra, or —NHC(═O)Rb;
each of Ra and Rb is independently C1-C6 alkyl or C6-C10 aryl;
each of R2 and R4 is independently —O— or —NRc—;
each Rc is independently H or C1-C6 alkyl;
each R3 is independently C6-C10 arylene, C3-C10 membered cycloalkylene, five to ten membered heteroarylene, three to ten membered heterocyclylene, C1-C10 alkylene, 2 to 1500 membered heteroalkylene, or C1-C10 alkylene or 2 to 1500 membered heteroalkylene each independently interrupted by a ring or ring system selected from the group consisting of C6-C10 arylene, C3-C10 membered cycloalkylene, five to ten membered heteroarylene, and three to ten membered heterocyclylene;
R5 is C6-C10 arylene, C3-C10 membered cycloalkylene, five to ten membered heteroarylene, three to ten membered heterocyclylene, —CH2OCH2—, —CH2O(CH2)1-6OCH2—, or C2-C10heteroalkylene comprising one or more oxo(═O) atoms;
each of m, n, p and q is independently 0, 1, 2, 3, 4, 5 or 6;
wherein each phenyl moiety in Formula (I), (II), (III), (IV) or (V) is optionally substituted with one or more R6; and
each R6 is independently selected from the group consisting of halo, cyano, hydroxy, amino, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, (C1-C6 alkyl)amino, (C1-C6 alkyl)hydroxy, (C1-C6 alkoxy)C1-C6 alkyl, and —O—(C1-C6 alkoxy)C1-C6 alkyl.