CPC C07K 7/02 (2013.01) [A61K 38/00 (2013.01)] | 25 Claims |
1. A cyclic peptide having the structure of Formula (I):
or a pharmaceutically acceptable salt thereof;
wherein:
A1 is an acyl or sulfonyl protected amino acid selected from the group consisting of
or is an acyl protected amine;
R4 is selected from the group consisting of the amino acid side chains of ALA, THR,
R5 is selected from the group consisting of the amino acid side chains of
R6 is selected from the group consisting of the amino acid side chains of
R7 is selected from the group consisting of the amino acid side chains of GLU,
R8 is selected from the group consisting of the amino acid side chains of HIS, GLU, TYR,
ALA;
R9 is selected from the group consisting of the amino acid side chains of
ALA, and GLU;
R10 is selected from the group consisting of the amino acid side chains of
P1 is H, methyl, an acetyl group, or
n is 0 or 1;
p is 2, 3, or 4;
wherein each amino acid residue is optionally an N-methylated amino acid; and
wherein each amino acid residue can be in the R or S configuration.
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