CPC C07K 16/46 (2013.01) [A61K 45/06 (2013.01); A61K 47/66 (2017.08); A61K 47/6811 (2017.08); A61K 47/6891 (2017.08); B82Y 5/00 (2013.01); C07K 14/47 (2013.01); C07K 14/475 (2013.01); C07K 14/485 (2013.01); C07K 14/65 (2013.01); C07K 16/44 (2013.01); C12N 15/62 (2013.01); A61K 38/00 (2013.01); C07K 2317/31 (2013.01); C07K 2317/76 (2013.01); C07K 2319/00 (2013.01); C07K 2319/80 (2013.01)] | 20 Claims |
1. A method for treating kidney tissue undergoing necrosis or apoptosis, the method comprising: administering to a subject in need thereof a therapeutically effective amount of a bi-specific fusion protein comprising Annexin V comprising an amino acid sequence having at least 99% identity with SEQ ID NO: 31, and IGF-1 comprising an amino acid sequence having at least 98.5% identity with SEQ ID NO: 3, so as to maintain viability of healthy kidney tissue cells.
|