CPC C07K 16/2827 (2013.01) [A61P 35/00 (2018.01); C07K 16/2818 (2013.01); G01N 33/57492 (2013.01); A61K 2039/505 (2013.01); A61K 2039/507 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/40 (2013.01); C07K 2317/41 (2013.01); C07K 2317/52 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/73 (2013.01); C07K 2317/732 (2013.01); C07K 2317/74 (2013.01); C07K 2317/75 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01)] | 48 Claims |
1. An isolated IgG antibody or antigen-binding fragment thereof that specifically binds to human B7-H4, comprising a heavy chain variable region (VH) complementarity determining region (CDR) 1, a VH CDR2, a VH CDR3 and a light chain variable region (VL) CDR1, a VL CDR2, and a VL CDR3 wherein the VH CDR1, VH CDR2, VH CDR3, VL CDR1, VL CDR2, and VL CDR3 comprise amino acid sequences selected from the group consisting of:
(a) SEQ ID NOs:458-463, respectively;
(b) SEQ ID NOs:5-10, respectively;
(c) SEQ ID NOs:15-20, respectively;
(d) SEQ ID NOs:25-30, respectively;
(e) SEQ ID NOs:35-40, respectively; and
(f) SEQ ID NOs:45-50, respectively.
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