CPC C07K 16/18 (2013.01) [A61K 39/3955 (2013.01); C07K 14/78 (2013.01); G01N 33/6893 (2013.01); A61K 2039/505 (2013.01); C07K 2317/33 (2013.01); C07K 2317/55 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/567 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2319/30 (2013.01)] | 24 Claims |
1. A method of treating cancer comprising administering to a subject an effective amount of an anti-fibrinogen-like globe (FBG) domain of a tenascin-C antibody or antigen binding fragment thereof, comprising a VH region wherein CDRH1 is SEQ ID NO: 9, CDRH2 is SEQ ID NO: 10, CDRH3 is independently selected from SEQ ID NO: 11, 30, 32, 34, 36, 38, 40, 42, 44, and 46, and a VL region wherein a CDRL1 is SEQ ID NO: 5, CDRL2 is SEQ ID NO: 13 and CDRL3 is SEQ ID NO: 14.
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