CPC C07K 14/43504 (2013.01) [A61K 47/65 (2017.08); A61P 29/00 (2018.01); A61K 38/00 (2013.01)] | 13 Claims |
1. A polypeptide comprising ziconotide, wherein the polypeptide is able to cross blood-brain barrier, wherein the polypeptide consists of ziconotide and a cell membrane penetrating peptide, or the polypeptide consists of ziconotide, a cell membrane penetrating peptide and a linker,
wherein C-terminal of the ziconotide is linked to N-terminal of a cell membrane penetrating peptide adjacently or via a linker, and
wherein the ziconotide has amino acids shown in SEQ ID NO.1, or the ziconotide is a variant of the amino acids shown in SEQ ID NO.1 with less than 4 amino acid deletions, mutations or insertions.
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