	US 11,814,412 B2
	Artificial proteins and compositions and methods thereof
Goutham Kodali, Malvern, PA (US); Molly Marie Sheehan, Philadelphia, PA (US); Joshua Mancini, Philadelphia, PA (US); Bohdana Marie Discher, Philadelphia, PA (US); Michael Magaraci, Philadelphia, PA (US); Nathan M. Ennist, Philadelphia, PA (US); Brian Chow, Cherry Hill, NJ (US); Peter Leslie Dutton, Media, PA (US); and Christopher Moser, Morrisville, PA (US)
Assigned to The Trustees of the University of Pennsylvania, Philadelphia, PA (US)
Filed by The Trustees of the University of Pennsylvania, Philadelphia, PA (US)
Filed on Jun. 29, 2021, as Appl. No. 17/362,552.
Application 17/362,552 is a division of application No. 15/773,891, granted, now 11,084,848, previously published as PCT/US2016/060677, filed on Nov. 4, 2016.
Claims priority of provisional application 62/251,171, filed on Nov. 5, 2015.
Claims priority of provisional application 62/250,812, filed on Nov. 4, 2015.
Prior Publication US 2021/0340183 A1, Nov. 4, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 14/00 (2006.01); G01N 33/68 (2006.01)

CPC C07K 14/001 (2013.01) [G01N 33/68 (2013.01)]

7 Claims

1. A composition comprising a peptide comprising one or more amino acid sequences of a formula selected from the group consisting of:

−XX+XX−−XX0+X−−XX00X−−XX0L (Generic Sequence A);

−X+0+X−−XX++X−−XX++X−−X+0+(Generic Sequence B);

+XX+XX−−XX0+X−−XX00X−−X+0L (Generic Sequence C); and

−XX+0+−−XX++X−−XX++X−−XX0+(Generic Sequence D);

wherein (+) represents a positively charged amino acid, (−) represents a negatively charged amino acid, (0) represents an amino acid having an amide side-chain, and (X) represents any amino acid; and

wherein the peptide comprises (SEQ ID No: 5)-LOOP-(SEQ ID No: 6)-LOOP-(SEQ ID No: 7)-LOOP-(SEQ ID No: 8), and wherein each occurrence of LOOP is independently selected from the group consisting of GGSGKGSGG (SEQ ID No: 17), GGCG (SEQ ID No: 18), GACG (SEQ ID No: 19), and GGSG (SEQ ID No; 20).