US 11,813,428 B2
Patch pump device for drug delivery
Antoine Barraud, Lonay (CH); Benjamin Pruijs, Bienne (CH); and Nathanael Sigg, Oulens-sous-Echallens (CH)
Assigned to Tandem Diabetes Care Switzerland Sárl, St-Sulpice (CH)
Filed by Tandem Diabetes Care Switzerland Sàrl, St-Sulpice (CH)
Filed on Dec. 19, 2022, as Appl. No. 18/068,255.
Application 18/068,255 is a continuation of application No. 16/769,566, granted, now 11,529,458, issued on Dec. 20, 2022, previously published as PCT/EP2018/084069, filed on Dec. 8, 2018.
Claims priority of application No. 17206304 (EP), filed on Dec. 8, 2017; and application No. 18157285 (EP), filed on Feb. 16, 2018.
Prior Publication US 2023/0122585 A1, Apr. 20, 2023
Int. Cl. A61M 5/142 (2006.01); A61M 5/145 (2006.01); A61M 5/168 (2006.01)
CPC A61M 5/14248 (2013.01) [A61M 5/1452 (2013.01); A61M 5/16809 (2013.01); A61M 2005/14268 (2013.01); A61M 2205/0216 (2013.01); A61M 2205/10 (2013.01); A61M 2205/3331 (2013.01)] 45 Claims
OG exemplary drawing
 
1. A patch pump for pumping liquid from a liquid reservoir to a subject for transcutaneous delivery of the liquid, the patch pump comprising:
a reusable portion comprising a first cavity configured to receive a first end of the liquid reservoir, the reusable portion comprising a pump; and
a disposable portion comprising a second cavity configured to receive a second end of the liquid reservoir, the disposable portion configured to be coupled to the reusable portion such that the liquid reservoir is held within the reusable portion and the disposable portion coupled together, the disposable portion configured to be separable from the reusable portion, the disposable portion comprising a tube configured to be fluidly connected to the liquid reservoir and a dosing unit downstream from the liquid reservoir configured to, responsive to pumping by the pump, supply a dose of the liquid to a delivery system outlet for transcutaneous delivery of the dose to the subject,
wherein the disposable portion further comprises a housing support with an adhesive base configured to bond to the subject's skin.
 
13. A patch pump for pumping liquid from a liquid reservoir to a subject for transcutaneous delivery of the liquid, the patch pump comprising:
a reusable portion comprising a first cavity configured to receive a first end of the liquid reservoir, the reusable portion comprising a pump, wherein the pump comprises a plunger actuator with a curved actuation rod configured to move, responsive to pumping by the pump, in a linear manner at a first end of the curved actuation rod, in the linear manner at a second end of the curved actuation rod, and to bend in a mid-section of the curved actuation rod; and
a disposable portion comprising a second cavity configured to receive a second end of the liquid reservoir, the disposable portion configured to be coupled to the reusable portion such that the liquid reservoir is held within the reusable portion and the disposable portion coupled together, the disposable portion configured to be separable from the reusable portion, the disposable portion comprising a tube configured to be fluidly connected to the liquid reservoir and a dosing unit downstream from the liquid reservoir configured to, responsive to pumping by the pump, supply a dose of the liquid to a delivery system outlet for transcutaneous delivery of the dose to the subject,
wherein the movement of the curved actuation rod in the linear manner causes the plunger actuator to push a plunger into the liquid reservoir to cause the liquid to be expelled out the liquid reservoir, into the tube, and towards the dosing unit.
 
17. A method of using a patch pump for pumping liquid from a liquid reservoir to a subject for transcutaneous delivery of the liquid, the method comprising:
inserting a first end of the liquid reservoir into a first cavity of a reusable portion comprising a pump;
coupling a disposable portion to the reusable portion such that a second cavity of the disposable portion receives a second end of the liquid reservoir and the liquid reservoir is held within the reusable portion and the disposable portion coupled together, the disposable portion comprising a tube configured to be fluidly connected to the liquid reservoir and a dosing unit downstream from the liquid reservoir;
adhering the reusable portion and the disposable portion coupled together to skin of the subject;
activating the pump to supply doses of the liquid to a delivery system outlet from the dosing unit for transcutaneous delivery of the doses to the subject;
after the doses have been transcutaneously delivered, separating the reusable portion from the disposable portion;
disposing of the disposable portion; and
reusing the reusable portion.
 
20. A patch pump for pumping liquid from a liquid reservoir to a subject for transcutaneous delivery of the liquid, the patch pump comprising:
a reusable portion configured to receive a first end of the liquid reservoir, the reusable portion comprising a pump and a plunger actuator with a curved actuation rod configured to move, responsive to pumping by the pump, in a linear manner at a first end of the curved actuation rod, in the linear manner at a second end of the curved actuation rod, and to bend in a mid-section of the curved actuation rod, further comprising a motor in the reusable portion and a reduction gear mechanism between the motor and the curved actuation rod, the motor configured to cause rotation, the reduction gear mechanism configured to cause a reduced rate of rotation compared to the rotation caused by the motor for movement of the curved actuation rod; and
a disposable portion configured to receive a second end of the liquid reservoir, the disposable portion configured to be coupled to the reusable portion such that the liquid reservoir is held within the reusable portion and the disposable portion coupled together, the disposable portion configured to be separable from the reusable portion, the disposable portion comprising a tube configured to be fluidly connected to the liquid reservoir and a dosing unit downstream from the liquid reservoir configured to, responsive to pumping by the pump, supply a dose of the liquid to a delivery system outlet for transcutaneous delivery of the dose to the subject,
wherein the movement of the curved actuation rod in the linear manner causes the plunger actuator to push a plunger into the liquid reservoir to cause the liquid to be expelled out the liquid reservoir, into the tube, and towards the dosing unit.
 
29. A patch pump for pumping liquid from a liquid reservoir to a subject for transcutaneous delivery of the liquid, the patch pump comprising:
a reusable portion configured to receive a first end of the liquid reservoir, the reusable portion comprising a pump; and
a disposable portion configured to receive a second end of the liquid reservoir, the disposable portion configured to be coupled to the reusable portion such that the liquid reservoir is held within the reusable portion and the disposable portion coupled together, the disposable portion configured to be separable from the reusable portion, the disposable portion comprising a tube configured to be fluidly connected to the liquid reservoir and a dosing unit downstream from the liquid reservoir configured to, responsive to pumping by the pump, supply a dose of the liquid to a delivery system outlet for transcutaneous delivery of the dose to the subject,
wherein the dosing unit comprises a chamber portion with a top wall and a bottom wall that separate apart as the chamber portion is filled with liquid,
wherein the bottom wall is bonded to a base, the bonding arranged along at least portions of a perimeter of the bottom wall such that when liquid is injected into the chamber portion and the top wall moves away from the bottom wall, an elastic tensile stress is generated in the top wall of the chamber portion.