	US 11,813,376 B2
	Cellular compositions derived from deceased donors to promote graft tolerance and manufacture and uses thereof
Michael Zdanowski, Fort Salonga, NY (US); Colby Suire, Houston, TX (US); and D. Scott Batty, Jr., San Carlos, CA (US)
Assigned to MEDEOR THERAPEUTICS, INC., South San Francisco, CA (US)
Filed by MEDEOR THERAPEUTICS, INC., South San Francisco, CA (US)
Filed on Sep. 18, 2019, as Appl. No. 16/574,867.
Claims priority of provisional application 62/732,823, filed on Sep. 18, 2018.
Prior Publication US 2020/0086006 A1, Mar. 19, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 35/12 (2015.01); A61L 27/38 (2006.01); C07K 14/725 (2006.01); C07K 14/74 (2006.01)

CPC A61L 27/3834 (2013.01) [A61K 35/12 (2013.01); C07K 14/7051 (2013.01); C07K 14/70539 (2013.01); A61K 2035/122 (2013.01); A61L 2430/40 (2013.01); C07K 2317/24 (2013.01)]

11 Claims

1. A cellular product for establishing mixed chimerism in a solid organ transplant recipient, the product comprising:

greater than 1×10⁵CD34⁺ cells/kg recipient weight derived from bone marrow obtained from a deceased donor, wherein said obtained bone marrow is contacted with an agent that mobilizes CD34+ cells; and

greater than 1×10⁵CD3⁺ cells/kg recipient weight derived from non-bone marrow of the deceased donor.