US 11,813,364 B2
Patch
Atsushi Sonobe, Tsukuba (JP); Takashi Yasukochi, Tsukuba (JP); and Yasunori Takada, Tsukuba (JP)
Assigned to HISAMITSU PHARMACEUTICAL CO., INC., Tosu (JP)
Filed by HISAMITSU PHARMACEUTICAL CO., INC., Tosu (JP)
Filed on Aug. 17, 2021, as Appl. No. 17/404,571.
Application 17/404,571 is a continuation of application No. 16/008,704, filed on Jun. 14, 2018, granted, now 11,123,305.
Application 16/008,704 is a continuation in part of application No. 14/416,983, granted, now 10,022,445, issued on Jul. 17, 2018, previously published as PCT/JP2013/070197, filed on Jul. 25, 2013.
Claims priority of application No. 2012-165793 (JP), filed on Jul. 26, 2012; and application No. 2013-078583 (JP), filed on Apr. 4, 2013.
Prior Publication US 2021/0369638 A1, Dec. 2, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/70 (2006.01); A61K 31/407 (2006.01); A61K 47/14 (2017.01); A61K 47/10 (2017.01); A61K 47/12 (2006.01)
CPC A61K 9/7069 (2013.01) [A61K 9/7053 (2013.01); A61K 31/407 (2013.01); A61K 47/10 (2013.01); A61K 47/14 (2013.01); A61K 9/7061 (2013.01); A61K 47/12 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A patch, comprising:
a support layer; and
an adhesive agent layer formed on the support layer and comprising asenapine and/or a pharmaceutically acceptable salt thereof, a maleic acid alkali salt, and a rubber-based adhesive agent such that a content of the maleic acid alkali salt in the adhesive agent layer is in a range of 1% by mass to 10% by mass,
wherein the adhesive agent layer includes free asenapine derived from the asenapine and/or pharmaceutically acceptable salt thereof such that a content of the free asenapine in the adhesive agent layer is in a range of 2% by mass to 10% by mass and that a mass ratio of the free asenapine to the rubber-based adhesive agent is in a range of 1:17 to 1:1.2.