	US 11,813,303 B2
	Hot flash ameliorant
Atsushi Suzuki, Shimotsuke (JP)
Assigned to KAO CORPORATION, Tokyo (JP)
Appl. No. 16/753,153
Filed by KAO CORPORATION, Tokyo (JP)
PCT Filed Oct. 3, 2018, PCT No. PCT/JP2018/037046 § 371(c)(1), (2) Date Apr. 2, 2020, PCT Pub. No. WO2019/069981, PCT Pub. Date Apr. 11, 2019.
Claims priority of application No. 2017-193174 (JP), filed on Oct. 3, 2017.
Prior Publication US 2020/0237845 A1, Jul. 30, 2020
Int. Cl. A61K 36/74 (2006.01); A61P 15/12 (2006.01); A61K 9/00 (2006.01); A61K 31/235 (2006.01)

CPC A61K 36/74 (2013.01) [A61K 9/0053 (2013.01); A61K 31/235 (2013.01); A61P 15/12 (2018.01)]

6 Claims

1. A method for improving hot flash, comprising orally administering a coffee bean extract to a subject in need thereof,

wherein the subject is a climacteric female having a symptom of hot flash,

wherein the coffee bean extract comprises at least one chlorogenic acid, and a mass ratio of caffeine to the at least one chlorogenic acid in the coffee bean extract is 0.015 or less, and

wherein from 100 to 500 mg per adult per day of the at least one chlorogenic acid is orally administered.