	US 11,813,262 B2
	Compositions and methods to increase muscular strength
Vivek Sivathanu, Cambridge, MA (US); and Roger Dale Kamm, Cambridge, MA (US)
Assigned to MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, MA (US)
Appl. No. 16/761,100
Filed by Massachusetts Institute of Technology, Cambridge, MA (US)
PCT Filed Nov. 2, 2018, PCT No. PCT/US2018/059087 § 371(c)(1), (2) Date May 1, 2020, PCT Pub. No. WO2019/090171, PCT Pub. Date May 9, 2019.
Claims priority of provisional application 62/581,690, filed on Nov. 4, 2017.
Prior Publication US 2020/0352940 A1, Nov. 12, 2020
Int. Cl. A61P 21/06 (2006.01); A61K 31/506 (2006.01); A61K 31/496 (2006.01)

CPC A61K 31/506 (2013.01) [A61K 31/496 (2013.01); A61P 21/06 (2018.01)]

21 Claims

1. A method for increasing muscle strength, comprising contacting a skeletal or smooth muscle of a subject in need thereof with a pharmacological agent comprising an F-actin disrupting agent at a dosage between about 0.01 to about 20 mg per kg of the subject applied for less than or equal to 5 hours to transiently depolymerize actin thereby reducing mechanical stiffness of a muscle tissue, wherein the F-actin disrupting agent comprises an actin nuclease inhibitor or tropomyosin inhibitor.