CPC A61K 31/44 (2013.01) [A61K 31/47 (2013.01); A61P 25/16 (2018.01)] | 4 Claims |
1. A method of treating Parkinson's disease in a subject comprising administering a therapeutically effective amount of a compound of Formula I
wherein, R1 is —NHC(O) C3-6 cycloalkyl and R2 is hydrogen;
or R1 and R2 along with the carbon atoms to which they are attached form a six membered aromatic ring, wherein the ring is substituted with one or more groups selected from hydrogen, halogen and C1-6 alkyl;
R3 and R4 are independently selected from group comprising hydrogen, halogen, C1-3 alkyl, OC1-3 alkyl, NO2, SC1-3 alkyl, C1-3 haloalkyl, OC1-3 haloalkyl, and SC1-3 haloalkyl, and wherein the compound of Formula I exhibits a ratio of concentration in brain to concentration in plasma of more than 0.15, and does not result in change in QT interval in the subject.
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