1. A method of treating a patient suffering from an advanced gastrointestinal stromal tumor with a wild-type KIT mutation, comprising:
orally administering to the patient a 150 mg ripretinib daily or twice daily, wherein the patient has previously been administered three or more kinase inhibitors before administration of the ripretinib, and where one of the previously administered kinase inhibitors is imatinib, and wherein the treatment provides more than 6 months of progression free survival in patients, as determined by mRECIST 1.1, after at least one cycle of 42 days of the daily ripretinib administration.