US 11,813,123 B2
Ultrasound responsive micro-composite markers
Jian Yang, San Diego, CA (US); Alexander Liberman, San Diego, CA (US); James Wang, San Diego, CA (US); Christopher Barback, San Diego, CA (US); Natalie Mendez, La Jolla, CA (US); Erin Ward, La Jolla, CA (US); Sarah Blair, La Jolla, CA (US); Andrew C. Kummel, San Diego, CA (US); Tsai-Wen Sung, Fremont, CA (US); and William C. Trogler, Del Mar, CA (US)
Assigned to THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US)
Appl. No. 16/329,669
Filed by The Regents of the University of California, Oakland, CA (US)
PCT Filed Aug. 31, 2017, PCT No. PCT/US2017/049714
§ 371(c)(1), (2) Date Feb. 28, 2019,
PCT Pub. No. WO2018/045222, PCT Pub. Date Mar. 8, 2018.
Claims priority of provisional application 62/381,739, filed on Aug. 31, 2016.
Prior Publication US 2019/0192253 A1, Jun. 27, 2019
Int. Cl. A61B 90/00 (2016.01); A61B 8/08 (2006.01); A61K 49/22 (2006.01); A61K 31/729 (2006.01); A61K 51/04 (2006.01); A61B 8/12 (2006.01); A61B 8/14 (2006.01)
CPC A61B 90/39 (2016.02) [A61B 8/0841 (2013.01); A61B 8/12 (2013.01); A61B 8/14 (2013.01); A61B 8/481 (2013.01); A61K 31/729 (2013.01); A61K 49/223 (2013.01); A61K 51/048 (2013.01); A61B 2090/3929 (2016.02); A61B 2562/0204 (2013.01); A61B 2562/12 (2013.01)] 20 Claims
OG exemplary drawing
 
1. An ultrasound activated marker, comprising:
a layer of polymeric matrix; and
hollow shells at least partially embedded in the layer of polymeric matrix, and positioned close to a top surface of the layer of polymeric matrix, wherein each of the hollow shells is configured to retain air in a hollow core and provide an ultrasound contrast agent for ultrasound imaging, and
wherein the hollow shells are silica hollow shells that are provided from polystyrene beads with an organic compound that includes diethylenetriamine (DETA) in a base solution including ethanol, and
wherein surfaces of the polystyrene beads are modified by the DETA that is adsorbed onto the surfaces of the polystyrene beads.