US 11,813,044 B2
Device and method for non-invasive assessment of maximum arterial compliance
Koen Theo Johan De Groot, Sevenum (NL); Antonius Hermanus Maria Akkermans, Veldhoven (NL); Cornelus Hendricus Bertus Arnoldus Van Dinther, Mierlo (NL); Stefan Pfundtner, Eindhoven (NL); David Antoine Christian Marie Roovers, Eindhoven (NL); Alphonsus Tarcisius Jozef Maria Schipper, Stramproy (NL); and Cornelis Harm Taal, Utrecht (NL)
Assigned to Koninklijke Philips N.V., Eindhoven (NL)
Appl. No. 16/309,950
Filed by KONINKLIJKE PHILIPS N.V., Eindhoven (NL)
PCT Filed Jun. 14, 2017, PCT No. PCT/EP2017/064632
§ 371(c)(1), (2) Date Dec. 14, 2018,
PCT Pub. No. WO2017/216268, PCT Pub. Date Dec. 21, 2017.
Claims priority of application No. EP16174325 (EP), filed on Jun. 14, 2016.
Prior Publication US 2019/0159688 A1, May 30, 2019
Int. Cl. A61B 5/021 (2006.01); A61B 5/02 (2006.01); A61B 5/022 (2006.01); A61B 5/00 (2006.01)
CPC A61B 5/02141 (2013.01) [A61B 5/02007 (2013.01); A61B 5/02225 (2013.01); A61B 5/6824 (2013.01); A61B 5/0059 (2013.01); A61B 5/02108 (2013.01); A61B 2562/0233 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A device for determining an arterial compliance of a subject, comprising:
an inflatable cuff which is attachable to a body part of the subject;
a pump adapted to inflate and a valve adapted to deflate the inflatable cuff;
a pressure sensor which is configured to sense a pressure signal that is indicative of a pressure within the inflatable cuff;
an optical sensor, which is at least partly integrated in the inflatable cuff, and is configured to sense a second signal that is responsive to expansions and contractions of the inflatable cuff caused by a pulsating blood flow in an artery of the subject; and
a processing unit which is configured:
to evaluate at least parts of the pressure signal and the second signal that are recorded while the inflatable cuff is attached to the body part of the subject and being deflated from above systolic pressure to below diastolic pressure over a plurality of cardiac cycles,
to determine based on said part of the pressure signal a pulse pressure (ΔP) of the subject,
to determine based on said part of the second signal an arterial volume change (ΔVart) of the artery of the subject for each cardiac cycle of the plurality of cardiac cycles recorded while the inflatable cuff is being deflated from above systolic pressure to below diastolic pressure; and
to determine the arterial compliance (C) of the subject
either by determining a maximum arterial volume change (ΔVart max) of the arterial volume changes (ΔVart) determined for each cardiac cycle of the plurality of cardiac cycles and dividing the maximum arterial volume change (ΔVart max) by the pulse pressure (ΔP),
or by dividing each of the determined arterial volume changes (ΔVart) of the plurality of cardiac cycles by the pulse pressure (ΔP) to receive a plurality of arterial compliance values, and then determining a maximum of the plurality of arterial compliance values.