| US 7,451,052 B2 | ||
| Application of comprehensive calibration to mass spectral peak analysis and molecular screening | ||
| Yongdong Wang, Wilton, Conn. (US); and Ming Gu, Yardley, Pa. (US) | ||
| Assigned to Cerno Bioscience LLC, Danbury, Conn. (US) | ||
| Filed on May 30, 2006, as Appl. No. 11/444,158. | ||
| Claims priority of provisional application 60/685129, filed on May 29, 2005. | ||
| Prior Publication US 2007/0023633 A1, Feb. 01, 2007 | ||
| Int. Cl. H01J 49/00 (2006.01) | ||
| U.S. Cl. 702—85 [702/76] | 91 Claims |
| 1. A method of performing mass spectral analysis involving at least one of the isotope satellites of at least one ion, comprising:
acquiring a measured mass spectral response including at least one isotope;
constructing a peak component matrix with mass spectral response functions;
performing a regression analysis between the acquired mass spectral response and the peak component matrix; and
reporting one of statistical measure and regression coefficients from the regression analysis for at least one of mass spectral
peak purity assessment, ion charge determination, mass spectral deconvolution, and mass shift compensation.
|