| US 7,448,379 B2 | ||
| Composition, vessel, dry powder inhalation system, and related methods for transpulmonary administration | ||
| Chikamasa Yamashita, Naruto (Japan); Shigeru Ibaragi, Tokushima-ken (Japan); Yuichiro Fukunaga, Tokushima-ken (Japan); and Akitsuna Akagi, Naruto (Japan) | ||
| Assigned to Otsuka Pharmaceutical Co., Ltd., Tokyo-to (Japan) | ||
| Filed on Jun. 14, 2002, as Appl. No. 10/170,339. | ||
| Claims priority of application No. 2001-182504 (JP), filed on Jun. 15, 2001; application No. 2001-400871 (JP), filed on Dec. 28, 2001; and application No. 2002-111131 (JP), filed on Apr. 12, 2002. | ||
| Prior Publication US 2003/0101995 A1, Jun. 05, 2003 | ||
| Int. Cl. A61M 15/00 (2006.01); A61M 16/00 (2006.01); B05D 7/14 (2006.01); B65D 83/06 (2006.01) | ||
| U.S. Cl. 128—203.15 [128/203.23] | 74 Claims |
| 1. A dry powder inhalation system for transpulmonary administration comprising:
(1) a vessel housing a freeze-dried composition that contains an active ingredient, wherein said freeze-dried composition
has:
(i) a non-powder form formed by freeze-drying without further processing,
(ii) a disintegration index of 0.015 or more, and
(iii) a property of becoming fine particles having a mean particle diameter of 10 microns or less or a fine particle fraction
of 10% or more upon receiving an air impact having an air speed of at least 1 in/sec and an air flow rate of at least 17 ml/sec;
and
(2) a device comprising a path to apply said air impact to the freeze-dried composition in said vessel, and a path to discharge
the freeze-dried composition in the form of fine particles.
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