US 7,448,184 B2
Method for forming a laminate assembly with an ultrasonic welder
Verna Lo Clark, Raleigh, N.C. (US); Michael Mary Van Oort, Durham, N.C. (US); and Richard Ian Walker, Ware (United Kingdom)
Assigned to Glaxo Group Limited, Greenford, Middlesex (United Kingdom)
Appl. No. 10/508,396
PCT Filed Mar. 25, 2003, PCT No. PCT/US03/09050
§ 371(c)(1), (2), (4) Date Sep. 21, 2004,
PCT Pub. No. WO03/095332, PCT Pub. Date Nov. 20, 2003.
Claims priority of provisional application 60/368107, filed on Mar. 26, 2002.
Prior Publication US 2005/0103678 A1, May 19, 2005
Int. Cl. B65B 51/22 (2006.01); B29C 65/08 (2006.01)
U.S. Cl. 53—453  [53/478; 53/559; 53/329.2; 53/374.4; 156/69; 156/73.3; 206/534.1] 25 Claims
OG exemplary drawing
 
1. A method for forming a laminate assembly, comprising the steps of:
a. providing a base sheet and a lid sheet, said base sheet having formed therein a blister pocket containing a pharmaceutical composition and comprising a first mating surface; said lid sheet comprising a second mating surface, said base and lid sheets having a primary seal formed between said first and second mating surfaces to form a primarily sealed laminate assembly;
b. exposing a portion of said primary sealed laminate assembly to a bonding device to create a secondary seal therein;
wherein said bonding device is an ultrasonic welder, said ultrasonic welder comprising a welding sonotrode and an anvil, and said primary sealed laminate assembly is positioned therebetween to form said laminate structure,
wherein said anvil comprises at least one rotary anvil defining an annular edge, and said avil comprises an axle having an axis of rotation and a pair of rotary anvils; a first rotary anvil having a first side extending generally tangentially from said axis of rotation and having a first annular edge; and a second rotary anvil having a second side extending generally tangentially from said axis of rotation and having a second annular edge; said first and second rotary anvils being spaced from each other, at least a portion of said first and second annular edges contacting said laminate structure during the creation of said secondary seal.