Methods and compositions for increasing red blood cells
Ravindra Kumar, Acton, MA (US); Rajasekhar Naga Venkata Sai Suragani, Norwood, MA (US); and John Knopf, Carlisle, MA (US)
Assigned to Acceleron Pharma Inc., Cambridge, MA (US)
Filed by Acceleron Pharma Inc., Cambridge, MA (US)
Filed on Oct. 6, 2020, as Appl. No. 17/063,848.
Application 17/063,848 is a continuation of application No. 16/422,117, filed on May 24, 2019, granted, now 10,829,534, issued on Nov. 10, 2020.
Application 16/422,117 is a continuation of application No. 15/783,056, filed on Oct. 13, 2017, granted, now 10,344,066, issued on Jul. 9, 2019.
Application 15/783,056 is a continuation of application No. 13/827,477, filed on Mar. 14, 2013, granted, now 9,809,636, issued on Nov. 7, 2017.
Claims priority of provisional application 61/621,154, filed on Apr. 6, 2012.
Prior Publication US 2021/0277082 A1, Sep. 9, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 14/51 (2006.01)
CPC C07K 14/51 (2013.01) [C07K 2319/02 (2013.01)]
19 Claims
1. A method for increasing red blood cell levels in a patient, the method comprising administering to a patient in need thereof a polypeptide selected from the group consisting of a BMP9 polypeptide comprising an amino acid sequence that is at least 90% identical to the sequence of SEQ ID NO: 3 and a BMP10 polypeptide comprising an amino acid sequence that is at least 90% identical to the sequence of SEQ ID NO: 6, wherein the polypeptide binds to ALK1 and increases red blood cell levels when administered to the patient.