	US 11,807,672 B2
	Conjugates of islet neogenesis peptides and analogs, and methods thereof
Liping Liu, Manassas, VA (US); and Ru Bai, Shenzhen (CN)
Assigned to Shenzhen HighTide Biopharmaceutical, Ltd., Shenzhen (CN)
Filed by SHENZHEN HIGHTIDE BIOPHARMACEUTICAL, LTD., Shenzhen (CN)
Filed on Oct. 4, 2020, as Appl. No. 17/062,622.
Application 17/062,622 is a continuation of application No. 16/074,073, granted, now 10,829,527, previously published as PCT/CN2017/076190, filed on Mar. 9, 2017.
Claims priority of provisional application 62/306,119, filed on Mar. 10, 2016.
Prior Publication US 2021/0122797 A1, Apr. 29, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 14/47 (2006.01); A61K 38/26 (2006.01); A61K 35/39 (2015.01); A61K 38/00 (2006.01); C12N 5/071 (2010.01)

CPC C07K 14/4705 (2013.01) [A61K 35/39 (2013.01); A61K 38/26 (2013.01); C07K 14/4723 (2013.01); C07K 14/4726 (2013.01); C12N 5/0676 (2013.01); A61K 38/00 (2013.01); C07K 2319/30 (2013.01); C12N 2501/335 (2013.01); C12N 2501/998 (2013.01)]

9 Claims

1. A compound having the formula of (I):

X-L-Y (I)

wherein

X is selected from islet neogenesis-associated protein peptide (INGAP-PP) or an analog thereof, or human proIslet peptide (HIP) or an analog thereof;

L is a linker selected from (EAAAK)_m, wherein m is 1, 2 or 3 (SEQ ID NO: 122), A(EAAAK)₄ALEA(EAAAK)₄A (SEQ ID NO: 124), AEAAAKEAAAKA (SEQ ID NO: 127), PAPAP (SEQ ID NO: 128) and (AP)_n, wherein n is an integer selected from 5-17 (SEQ ID NO: 129); and

Y is an epidermal growth factor receptor agonist or a cathelicidin antimicrobial peptide, or an analog thereof.