US 11,807,667 B2
Thermostable viral reverse transcriptase
Thomas William Schoenfeld, Topsfield, MA (US); Ryan Charles Heller, Amesbury, MA (US); Katarzyna Crissy, Windham, NH (US); and Suhman Chung, South Hamilton, MA (US)
Assigned to QIAGEN BEVERLY, LLC., Beverly, MA (US)
Appl. No. 17/052,237
Filed by QIAGEN BEVERLY, LLC, Beverly, MA (US)
PCT Filed Apr. 30, 2019, PCT No. PCT/IB2019/053537
§ 371(c)(1), (2) Date Nov. 2, 2020,
PCT Pub. No. WO2019/211749, PCT Pub. Date Nov. 7, 2019.
Claims priority of provisional application 62/665,560, filed on May 2, 2018.
Claims priority of provisional application 62/790,483, filed on Jan. 10, 2019.
Claims priority of provisional application 62/835,521, filed on Apr. 18, 2019.
Claims priority of application No. 18173195 (EP), filed on May 18, 2018.
Prior Publication US 2021/0171580 A1, Jun. 10, 2021
Int. Cl. C12N 9/12 (2006.01); C07K 14/00 (2006.01); C12Q 1/6844 (2018.01)
CPC C07K 14/00 (2013.01) [C12N 9/1276 (2013.01); C12Q 1/6844 (2013.01); C12Q 2531/113 (2013.01)] 15 Claims
 
1. A polypeptide comprising a first amino acid sequence and a second amino acid sequence,
wherein the first amino acid sequence comprises an amino acid sequence of SEQ ID NO:16 or an amino acid sequence at least 90% identical to SEQ ID NO:16, and
wherein the second amino acid sequence is selected from the group consisting of SEQ ID NO:17 and SEQ ID NO:72, or an amino acid sequence at least 90% identical to SEQ ID NO:17 or SEQ ID NO:72,
wherein the polypeptide has polymerase activity.