US 11,807,635 B2
Nitrile derivative that acts as inhibitor of dipeptidyl peptidase 1 and use thereof
Yao Li, Sichuan (CN); Zongjun Shi, Sichuan (CN); Guobiao Zhang, Sichuan (CN); Lei Chen, Sichuan (CN); Wenjing Wang, Sichuan (CN); Xiaobo Zhang, Sichuan (CN); Dengyu Zheng, Sichuan (CN); Bo Xu, Sichuan (CN); Xin Liu, Sichuan (CN); Yajun Wang, Sichuan (CN); Fei Ye, Sichuan (CN); Pingming Tang, Sichuan (CN); Jia Ni, Sichuan (CN); Chen Zhang, Sichuan (CN); and Pangke Yan, Sichuan (CN)
Assigned to Haisco Pharmaceuticals Pte. Ltd., Singapore (SG)
Filed by HAISCO PHARMACEUTICALS PTE. LTD, Singapore (SG)
Filed on Oct. 28, 2022, as Appl. No. 17/976,291.
Application 17/976,291 is a continuation of application No. PCT/CN2021/114500, filed on Aug. 25, 2021.
Claims priority of application No. 202010871912.1 (CN), filed on Aug. 26, 2020; application No. 202011129809.6 (CN), filed on Oct. 21, 2020; and application No. 202110167731.5 (CN), filed on Feb. 7, 2021.
Prior Publication US 2023/0121807 A1, Apr. 20, 2023
Int. Cl. C07D 413/12 (2006.01); C07D 267/10 (2006.01); C07D 413/14 (2006.01); C07D 417/12 (2006.01); C07F 9/6527 (2006.01)
CPC C07D 413/12 (2013.01) [C07D 267/10 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01); C07F 9/6527 (2013.01)] 12 Claims
 
1. A compound, or the stereoisomer, deuterated product, solvate or pharmaceutically acceptable salt thereof, wherein the compound has a structure of formula (IV):

OG Complex Work Unit Chemistry
wherein
Rc is H, halogen, C1-2 alkyl or C1-2 alkoxy;
R1, R2, and R3 are each independently selected from H, deuterium, F, Cl, Br, methyl, ethyl, methoxy or ethoxy, and the methyl, ethyl, methoxy or ethoxy is optionally substituted with 1-3 groups selected from F, Cl, Br, cyano, hydroxyl, and NH2;
Z is CH or N;
ring G is

OG Complex Work Unit Chemistry
or a benzene ring, each of which is optionally substituted with 1-2 RG groups; and
each RG is independently selected from F, Cl, Br, I, methyl, ethyl, propyl, SF5 and CN, wherein the methyl, ethyl or propyl is optionally further substituted with 1-3 groups selected from deuterium, F, Cl, Br, and I.