CPC C07D 413/12 (2013.01) | 27 Claims |
1. A compound of Formula (I):
an enantiomer, diastereoisomer, atropisomer thereof, a mixture thereof, or a pharmaceutically acceptable salt thereof, wherein:
R1 is a cyclopropyl ring; or a 4-, 5-, 6-, 7-, or 8-membered bicyclic ring containing 0, 1, 2 or 3 N atoms and 0, 1, or 2 atoms selected from O and S; and wherein said cyclopropyl ring or bicyclic ring is substituted by 0, 1, 2 or 3 R1a groups selected from hydroxy, halo, C1-8alk, C1-8haloalk, —O—C1-4alk, —O—C1-8haloalk, —C(═O)C1-4alk, —O—C(═O)C1-4alk, —NH2,
—NHC1-4alk, —N(C1-4alk)C1-4alk, 3-, 4-, or 5-membered cycloalkyl, or 6-membered aryl;
R2 is H, halo, CN, C1-6alk, or C1-6haloalk;
R3 is C1-6alk, C1-6haloalk, —O—C1-6alk, —O-cyclopropyl, or —O-cyclobutyl;
R4 is a 5- to 6-membered heteroaryl;
Each of R6 and R7 is hydrogen; and
Each of R5a; R5b; R5c; R5d; and R5e is independently hydrogen or halo,
wherein the compound is not
or a salt or tautomer thereof.
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