US 11,807,603 B2
Cross-linked polyglycerol esters
Jan Marian Von Hof, Bochum (DE); Achim Friedrich, Hattingen (DE); Wolfgang Berkels, Bottrop (DE); Barbara Hohenberg, Gelsenkirchen (DE); Oliver Springer, Wesel (DE); and Juergen Meyer, Essen (DE)
Assigned to Evonik Operations GmbH, Essen (DE)
Appl. No. 16/322,566
Filed by Evonik Operations GmbH, Essen (DE)
PCT Filed May 15, 2017, PCT No. PCT/EP2017/061563
§ 371(c)(1), (2) Date Feb. 1, 2019,
PCT Pub. No. WO2018/033259, PCT Pub. Date Feb. 22, 2018.
Claims priority of application No. 16184676 (EP), filed on Aug. 18, 2016.
Prior Publication US 2019/0202771 A1, Jul. 4, 2019
Int. Cl. C07C 69/675 (2006.01); C07C 67/08 (2006.01); A61K 47/14 (2017.01); A61K 8/06 (2006.01); A61Q 19/00 (2006.01); A61K 8/39 (2006.01); C09K 23/00 (2022.01); A61K 8/37 (2006.01); A61Q 1/02 (2006.01); A61Q 15/00 (2006.01); A61Q 17/04 (2006.01)
CPC C07C 69/675 (2013.01) [A61K 8/064 (2013.01); A61K 8/375 (2013.01); A61K 8/39 (2013.01); A61K 47/14 (2013.01); A61Q 1/02 (2013.01); A61Q 15/00 (2013.01); A61Q 17/04 (2013.01); A61Q 19/00 (2013.01); A61Q 19/007 (2013.01); C07C 67/08 (2013.01); C09K 23/00 (2022.01); A61K 2800/10 (2013.01)] 20 Claims
 
1. A quick-break emulsion comprising
a polyglycerol partial ester obtained by esterification of a polyglycerol with a carboxylic acid mixture comprising:
a) a polyhydroxycarboxylic acid of a hydroxycarboxylic acid having from 14 to 18 carbon atoms,
b) at least one short-chain dicarboxylic acid having from 2 to 16 carbon atoms,
c) at least one long-chain dicarboxylic acid having from 34 to 38 carbon atoms, and
d) at least one fatty acid selected from linear, unsaturated and branched, saturated fatty acids having from 14 to 24 carbon atoms;
wherein the polyglycerol comprises
i. from 0 to 15% by weight of glycerol,
ii. from 10 to 40% by weight of diglycerol,
iii. from 10 to 50% by weight of triglycerol,
iv. from 5 to 25% by weight of tetraglycerol, and
v. from 0 to 55% by weight of pentaglycerol and higher glycerols;
wherein the polyglycerol has a hydroxyl number of from 1520 to 845 and wherein the carboxylic acid mixture of a), b), c) and d) make up at least 80% by weight based on the total carboxylic acid mixture; and
wherein, in the esterification, the molar ratio of b) to c) is from 0.5:1.0 to 1.0:0.5, and wherein the quick-break emulsion contains an internal aqueous phase of from 83% by weight to 94.5% by weight and an external oil phase in an amount of from 5% by weight to 17% by weight, and from 0.5% by weight to 2.0% by weight of the polyglycerol partial ester, wherein the % by weight is based on the total emulsion.