US 11,806,676 B2
Compositions for use in the simultaneous removal of endotoxins and uremic solutes during the treatment of patients
Dimitrios Stamatialis, Deventer (NL); and Ilaria Geremia, Teglio Veneto (IT)
Assigned to Universiteit Twente, Enschede (NL)
Appl. No. 17/262,301
Filed by Universiteit Twente, Enschede (NL)
PCT Filed Jul. 25, 2019, PCT No. PCT/NL2019/050484
§ 371(c)(1), (2) Date Jan. 22, 2021,
PCT Pub. No. WO2020/022894, PCT Pub. Date Jan. 30, 2020.
Claims priority of application No. 18185495 (EP), filed on Jul. 25, 2018.
Prior Publication US 2021/0252462 A1, Aug. 19, 2021
Int. Cl. B01D 69/14 (2006.01); B01D 69/02 (2006.01); B01D 71/62 (2006.01); B01D 71/68 (2006.01); A61M 1/34 (2006.01); A61M 1/16 (2006.01); B01D 71/02 (2006.01); B01J 20/20 (2006.01); B01J 20/28 (2006.01); B01J 20/32 (2006.01)
CPC B01D 69/147 (2013.01) [A61M 1/34 (2013.01); B01D 69/02 (2013.01); B01D 71/021 (2013.01); B01D 71/62 (2013.01); B01D 71/68 (2013.01); B01J 20/20 (2013.01); B01J 20/28026 (2013.01); B01J 20/28038 (2013.01); B01J 20/28085 (2013.01); B01J 20/321 (2013.01); B01J 20/324 (2013.01); B01J 20/3212 (2013.01); A61M 1/1696 (2013.01); B01D 2325/36 (2013.01)] 5 Claims
OG exemplary drawing
 
1. A method of hemodialysis or hemodiafiltration treatment of patients, wherein said method comprises the step of
simultaneously removing endotoxins from dialysate and uremic solutes from blood by contacting said dialysate and said blood with a composition comprising sorbent particles;
wherein said particles are embedded into a membrane, said membrane comprising at least one polymer selected from the group consisting of polysulfone, polyethersulfone, polyphenylenesulfone, polyarylethersulfone, polyamide, polyetherimide, polyimide, polyethylene-co-vinyl alcohol, polyethylene-co-vinyl acetate, cellulose acetate, cellulose triacetate, polyvinylidene fluoride, polyvinylchloride, polyacrylonitrile, polyurethane, polyether ether ketone, and polyacrylic acid;
wherein said membrane further comprises at least one hydrophilic additive selected from the group consisting of polyvinylpyrrolidone, polyethylene glycol, dextran, glycerol, diethylene glycol, octanol, oxalic acid, maleic acid, tartaric acid, fumaric acid, lithium chloride, and calcium chloride;
whereby in said treatment the dialysate comprises endotoxins at a concentration of at least 0.03 EU/mL when the dialysate is first brought into contact with said membrane.