US 11,806,504 B2
Device, system and methods for the oral delivery of therapeutic compounds
Mir A. Imran, Los Altos Hills, CA (US); Peter Herrmann, San Jose, CA (US); Baber Syed, Palo Alto, CA (US); Timothy H. Williams, Campbell, CA (US); Chang Jin Ong, Fremont, CA (US); and Greg Method, San Jose, CA (US)
Assigned to RANI THERAPEUTICS, LLC, San Jose, CA (US)
Filed by Rani Therapeutics, LLC, San Jose, CA (US)
Filed on Mar. 24, 2020, as Appl. No. 16/828,914.
Application 16/828,914 is a continuation of application No. 15/674,421, filed on Aug. 10, 2017, granted, now 10,632,251.
Application 15/674,421 is a continuation of application No. 14/244,673, filed on Apr. 3, 2014, granted, now 9,757,514, issued on Sep. 12, 2017.
Application 14/244,673 is a continuation of application No. 13/837,025, filed on Mar. 15, 2013, granted, now 8,734,429, issued on May 27, 2014.
Application 13/837,025 is a continuation in part of application No. 13/532,589, filed on Jun. 25, 2012, granted, now 9,149,617, issued on Oct. 6, 2015.
Application 13/532,589 is a continuation in part of application No. 12/978,301, filed on Dec. 23, 2010, granted, now 8,562,589, issued on Oct. 22, 2013.
Application 12/978,301 is a continuation in part of application No. 12/978,233, filed on Dec. 23, 2010, granted, now 8,721,620, issued on May 13, 2014.
Claims priority of provisional application 61/571,641, filed on Jun. 29, 2011.
Prior Publication US 2020/0289747 A1, Sep. 17, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. A61M 5/155 (2006.01); A61M 5/142 (2006.01); A61K 38/13 (2006.01); A61K 38/21 (2006.01); A61K 38/26 (2006.01); A61K 38/27 (2006.01); A61K 38/28 (2006.01); A61K 38/29 (2006.01); A61K 38/30 (2006.01); A61K 38/55 (2006.01); A61M 31/00 (2006.01); A61K 9/48 (2006.01); A61M 37/00 (2006.01)
CPC A61M 5/155 (2013.01) [A61K 38/13 (2013.01); A61K 38/21 (2013.01); A61K 38/26 (2013.01); A61K 38/27 (2013.01); A61K 38/28 (2013.01); A61K 38/29 (2013.01); A61K 38/30 (2013.01); A61K 38/55 (2013.01); A61M 5/14244 (2013.01); A61M 31/002 (2013.01); A61K 9/4808 (2013.01); A61M 37/0069 (2013.01); A61M 2205/3331 (2013.01); A61M 2210/1042 (2013.01)] 16 Claims
OG exemplary drawing
 
1. An ingestible device suitable for swallowing into a lumen of a gastrointestinal tract of a patient, the lumen having a lumen wall, the device comprising:
a capsule sized to pass through the gastrointestinal tract;
a drug preparation;
a tissue penetrating member disposed in the capsule, the tissue penetrating member comprising the drug preparation; and
a delivery mechanism for advancing the tissue penetrating member from the capsule to the lumen wall, the delivery mechanism comprising:
an expandable member; and
a piston-cylinder assembly operably coupled to the expandable member and to the tissue penetrating member, wherein the piston-cylinder assembly comprises a piston slidably disposed in a cylinder, wherein the piston-cylinder assembly is at least partially disposed in the expandable member;
wherein the expandable member is configured to expand to cause the piston-cylinder assembly to apply a force against the tissue penetrating member and advance the drug preparation into the lumen wall.