CPC A61K 35/761 (2013.01) [A61K 48/005 (2013.01); A61P 35/00 (2018.01); C12N 7/00 (2013.01); C12N 15/113 (2013.01); C12N 15/1135 (2013.01); C12N 15/63 (2013.01); C12N 15/64 (2013.01); C12N 2310/531 (2013.01); C12N 2710/10332 (2013.01); C12N 2710/10343 (2013.01)] | 26 Claims |
1. An isolated recombinant oncolytic adenovirus, wherein the recombinant oncolytic adenovirus is a selectively replicating oncolytic adenovirus and the genome of the recombinant oncolytic adenovirus is integrated with a coding sequence of an exogenous shRNA capable of inhibiting the expression of PDL1 in tumor cells; wherein the coding sequence of the exogenous shRNA is as shown in any one of SEQ ID NOs. 16, 19, and 22.
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