CPC A61K 35/28 (2013.01) [A61K 35/545 (2013.01); C12N 5/0662 (2013.01); C12N 5/0663 (2013.01); C12Q 1/6881 (2013.01); C12Y 205/01018 (2013.01); C12Q 2600/158 (2013.01)] | 5 Claims |
1. A method for selecting a stem cell donor, the method comprising:
(a) determining the genotype for GSTT1 in a DNA-containing sample isolated from an individual, and selecting as the stem cell donor an individual determined to have a GSTT1 genotype which is known, and/or which would be predicted, to result in decreased expression of GSTT1 relative to individuals homozygous for wildtype; or
(b) determining the level of GSTT1 expression by a stem cell or plurality of stem cells in a sample isolated from an individual, and comparing the determined level of GSTT1 expression to a reference value for the level of GSTT1 expression for that stem cell type, and selecting as the stem cell donor an individual determined to have a stem cell or plurality of stem cells having decreased GSTT1 expression relative to the reference value,
the method further comprising separating and/or isolating a stem cell or plurality of stem cells from the individual selected as a stem cell donor, wherein the stem cell or plurality of stem cells separated and/or isolated from the individual selected as the stem cell donor is a mesenchymal stem cell (MSC) or plurality of MSCs obtained from the bone marrow of the individual selected as a stem cell donor.
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