CPC A61K 35/15 (2013.01) [C12N 5/0669 (2013.01); C12N 2501/22 (2013.01); C12N 2501/2306 (2013.01); C12N 2501/24 (2013.01)] | 15 Claims |
1. A method for producing myeloid-derived suppressor cells (MDSCs), comprising: a step of treating bone marrow cells with a toll-like receptor agonist (TLR agonist) or type I interferon, to induce differentiation into myeloid-derived suppressor cells,
wherein the toll-like receptor agonist is at least one of toll-like receptor 7 agonist and toll-like receptor 9 agonist,
wherein the myeloid-derived suppressor cells comprise MDSCs having phenotype PDCA-1+, and
wherein the toll-like receptor agonist or the type I interferon is applied at the initiation time of bone marrow cell differentiation, and then is applied one or more times within 3 days after the initiation of differentiation.
|