US 11,806,362 B2
Heparin and heparan sulphate oligosaccharides
Raymond Alexander Alfred Smith, Singapore (SG); Simon McKenzie Cool, Singapore (SG); Victor Nurcombe, Singapore (SG); and Sadasivam Murali, Tamil Nadu (IN)
Assigned to Agency for Science, Technology and Research, Singapore (SG)
Filed by Agency for Science, Technology and Research, Singapore (SG)
Filed on Apr. 25, 2022, as Appl. No. 17/728,503.
Application 17/728,503 is a continuation of application No. 16/770,721, granted, now 11,331,337, previously published as PCT/SG2018/050602, filed on Dec. 11, 2018.
Claims priority of application No. 10201710287Y (SG), filed on Dec. 11, 2017.
Prior Publication US 2022/0347205 A1, Nov. 3, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/727 (2006.01)
CPC A61K 31/727 (2013.01) 20 Claims
 
1. A biomaterial that is coated and/or impregnated with an isolated heparin or heparan sulphate oligosaccharide, wherein the isolated heparin oligosaccharide has a chain length of at least dp12 and no more than dp50, and wherein the isolated heparan sulphate oligosaccharide has a chain length of at least dp36 and no more than dp50, and wherein the isolated heparin or heparan sulphate oligosaccharide is capable of binding BMP2.