	US 11,806,326 B2
	Methods for dopamine modulation in human neurologic diseases
Jonathan Sackner-Bernstein, Pleasantville, NY (US)
Appl. No. 16/965,466
Filed by Jonathan Sackner-Bernstein, Pleasantville, NY (US)
PCT Filed Jan. 25, 2019, PCT No. PCT/US2019/015143 § 371(c)(1), (2) Date Jul. 28, 2020, PCT Pub. No. WO2019/147934, PCT Pub. Date Aug. 1, 2019.
Claims priority of provisional application 62/650,813, filed on Mar. 30, 2018.
Claims priority of provisional application 62/623,348, filed on Jan. 29, 2018.
Prior Publication US 2021/0052531 A1, Feb. 25, 2021
Int. Cl. A61K 31/198 (2006.01); A61K 45/06 (2006.01); A61K 47/02 (2006.01)

CPC A61K 31/198 (2013.01) [A61K 45/06 (2013.01); A61K 47/02 (2013.01)]

27 Claims

1. Methods of treating Parkinson's disease and/or Parkinsonism by antagonizing tyrosine hydroxylase via administering to a human patient in need thereof, a composition comprising one or more of the competitive inhibitors of tyrosine hydroxylase including alpha-methyl-p-tyrosine, wherein the alpha-methyl-p-tyrosine is administered at a nominal dose or doses and then administered in a therapeutic dose or doses that are gradually increased over days or weeks.