CPC A61K 31/137 (2013.01) [A61K 9/08 (2013.01); A61K 47/547 (2017.08); A61L 2/0017 (2013.01); A61J 1/14 (2013.01); A61L 2202/21 (2013.01)] | 18 Claims |
1. A storage stable sterile ready-to-administer pharmaceutical composition, comprising:
a buffered aqueous solution comprising isoproterenol at a concentration of between 1-10 mcg/mL;
wherein the buffered aqueous solution has a pH range of between 3.0 and 4.5 and wherein the buffer is a tartrate buffer and has a concentration of equal to or less than 10 mM;
wherein the solution further comprises ethylenediamine tetraacetic acid (EDTA) as a chelating agent at a concentration of about 5 mcg/mL and a tonicity agent;
wherein the ready-to-administer composition contains, after storage over at least three weeks at 60° C. in a container having a headspace that has not been flushed with an inert gas, equal to or less than 2.0% of total impurities formed from degradation of the isoproterenol, and
wherein the composition is formulated for intravenous administration and is antioxidant free.
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