US 11,806,318 B2
Nanoemulsion compositions for preventing, suppressing or eliminating allergic and inflammatory disease
James R. Baker, Jr., Ann Arbor, MI (US); Anna U. Bielinska, Ann Arbor, MI (US); Douglas Smith, Ann Arbor, MI (US); Paul E. Makidon, Ann Arbor, MI (US); and Jessica J. O'Konek, Ann Arbor, MI (US)
Assigned to THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US)
Filed by THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US)
Filed on Jul. 6, 2021, as Appl. No. 17/368,366.
Application 17/368,366 is a continuation of application No. 15/517,916, granted, now 11,083,788, previously published as PCT/US2015/054943, filed on Oct. 9, 2015.
Claims priority of provisional application 62/062,644, filed on Oct. 10, 2014.
Prior Publication US 2021/0401975 A1, Dec. 30, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 39/35 (2006.01); A61K 9/107 (2006.01); A61K 9/00 (2006.01); A61K 47/22 (2006.01); A61K 47/44 (2017.01); A61K 47/26 (2006.01); A61K 9/14 (2006.01); A61K 39/00 (2006.01); A61K 39/29 (2006.01); C12N 7/00 (2006.01)
CPC A61K 39/35 (2013.01) [A61K 9/0043 (2013.01); A61K 9/1075 (2013.01); A61K 9/143 (2013.01); A61K 39/292 (2013.01); A61K 47/22 (2013.01); A61K 47/26 (2013.01); A61K 47/44 (2013.01); C12N 7/00 (2013.01); A61K 2039/543 (2013.01); A61K 2039/545 (2013.01); A61K 2039/55505 (2013.01); A61K 2039/55511 (2013.01); A61K 2039/55566 (2013.01); A61K 2039/57 (2013.01); C12N 2730/10134 (2013.01)] 13 Claims
 
1. A method for treating an allergy in a subject, which comprises intranasally administering to the subject a therapeutically effective amount of an immunogenic composition comprising an allergen and a nanoemulsion, wherein:
(a) the subject has an established Th2 polarized immune response prior to administering the immunogenic composition; and
(b) the nanoemulsion comprises oil, water, ethanol, a polysorbate surfactant and a cationic compound, whereupon the allergy is treated.