US 11,806,315 B2
Compositions and methods for small canines
Rondo P Middleton, Creve Coeur, MO (US); Gail Czarnecki-Maulden, Edwardsville, IL (US); Christina Petzinger Germain, Imperial, MO (US); Alison Beloshapka, St. Louis, MO (US); James Kaput, Lausanne (CH); and Steven S Hannah, Chesterfield, MO (US)
Assigned to SOCIÉTÉ DES PRODUITS NESTLÉ S.A., Vevey (CH)
Filed by SOCIÉTÉ DES PRODUITS NESTLÉ S.A., Vevey (CH)
Filed on Dec. 12, 2017, as Appl. No. 15/839,294.
Claims priority of provisional application 62/434,564, filed on Dec. 15, 2016.
Prior Publication US 2018/0169155 A1, Jun. 21, 2018
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 35/741 (2015.01); A61K 9/00 (2006.01); A61K 35/745 (2015.01); A61K 35/747 (2015.01); A61P 3/02 (2006.01); A61P 1/00 (2006.01); A61K 36/064 (2006.01); A61K 36/062 (2006.01); A61K 45/06 (2006.01); A23K 10/18 (2016.01); A23K 20/142 (2016.01); A23K 20/174 (2016.01); A23K 20/24 (2016.01); A23K 20/26 (2016.01); A23K 50/42 (2016.01); A23K 20/10 (2016.01); A23K 20/163 (2016.01); A23K 20/111 (2016.01); A23K 20/20 (2016.01); A61K 31/198 (2006.01); A23K 50/40 (2016.01); A23K 20/179 (2016.01)
CPC A61K 35/741 (2013.01) [A23K 10/18 (2016.05); A23K 20/10 (2016.05); A23K 20/111 (2016.05); A23K 20/142 (2016.05); A23K 20/163 (2016.05); A23K 20/174 (2016.05); A23K 20/179 (2016.05); A23K 20/24 (2016.05); A23K 20/26 (2016.05); A23K 20/30 (2016.05); A23K 50/40 (2016.05); A23K 50/42 (2016.05); A61K 9/0056 (2013.01); A61K 31/198 (2013.01); A61K 35/745 (2013.01); A61K 35/747 (2013.01); A61K 36/062 (2013.01); A61K 36/064 (2013.01); A61K 45/06 (2013.01); A61P 1/00 (2018.01); A61P 3/02 (2018.01); A23V 2002/00 (2013.01)] 10 Claims
 
1. A method of increasing amino acid absorption in a small dog, the method comprising administering to the small dog a pet food composition comprising:
a plurality of amino acids comprising at least one amino acid selected from the group consisting of phenylalanine, tyrosine, and a combination of phenylalanine and tyrosine, in an amount of about 4.8 g to about 25 g per 1,000 kcal of metabolizable energy (ME); and the plurality of amino acids further comprising lysine in an amount of about 2.8 g to about 25 g per 1,000 kcal ME;
a probiotic selected from the group consisting of Bifidobacterium, Enterococcus, Bacillus, Lactobacillus, Pediococcus, Aspergillus, Leuconostoc, Megasphaera, Propionibacterium, Saccharomyces, and mixtures thereof; and
at least three antioxidants selected from the group consisting of vitamin E in an amount from about 35 IU to about 1,000 IU per 1,000 kcal of ME, vitamin C in an amount from about 1 mg to about 1,000 mg per 1,000 kcal ME, vitamin A in an amount of about 4,700 IU to about 65,500 IU per 1,000 kcal ME, selenium in an amount of about 0.13 mg to about 0.5 mg per 1,000 kcal ME, lycopene in an amount of about 1 mg to about 100 mg per kg of the pet food composition, carotenoids in an amount of about 1 mg to about 100 mg per kg of the pet food composition, proanthocyanidins in an amount of about 1 mg to about 100 mg per kg of the pet food composition, bioflavonoids in an amount of about 1 mg to about 100 mg per kg of the pet food composition, and catechins in an amount of about 1 mg to about 100 mg per kg of the pet food composition;
wherein the pet food composition provides about 2,500 to about 6,000 kcal of the ME per kg of the pet food composition on a dry matter basis,
wherein the pet food composition has at least one formulation selected from the group consisting of:
(a) the pet food composition comprises at least three metabolites for modulating antioxidant concentration in the small dog and each selected from the group consisting of 5-oxoproline, gamma-glutamylphenylalanine, urate, gamma-glutamylisoleucine, gamma-glutamylleucine, gamma-glutamylvaline, gamma-glutamyltyrosine, xylonate, arabonate, gamma-glutamylmethionine, gulono-1,4-lactone, bilirubin, cysteine-glutathione disulfide, and threonate, and
(b) the pet food composition comprises at least three metabolites for modulating amino acid concentration in the small dog and each selected from the group consisting of phenylalanine, p-cresolsulfate, phenol sulfate, and glutamine.