US 11,806,001 B2
Localized fusion of native leaflets using activated adhesive
Hengchu Cao, Irvine, CA (US); Shih-Hwa Shen, Irvine, CA (US); Holly Kung Jung Hsu, Irvine, CA (US); and Krystal Ya-Fong Lai, Irvine, CA (US)
Assigned to EDWARDS LIFESCIENCES CORPORATION, Irvine, CA (US)
Filed by Edwards Lifesciences Corporation, Irvine, CA (US)
Filed on Apr. 16, 2020, as Appl. No. 16/850,950.
Application 16/850,950 is a continuation of application No. PCT/US2018/056016, filed on Oct. 16, 2018.
Claims priority of provisional application 62/575,252, filed on Oct. 20, 2017.
Prior Publication US 2020/0237357 A1, Jul. 30, 2020
Int. Cl. A61B 17/00 (2006.01); A61F 2/24 (2006.01); A61F 2/90 (2013.01)
CPC A61B 17/00491 (2013.01) [A61F 2/246 (2013.01); A61F 2/90 (2013.01); A61B 2017/005 (2013.01); A61B 2017/00243 (2013.01); A61B 2017/00495 (2013.01); A61B 2017/00522 (2013.01); A61B 2017/00557 (2013.01); A61F 2/2442 (2013.01); A61F 2/2445 (2013.01); A61F 2/2466 (2013.01); A61F 2250/0059 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A delivery device for application of an adhesive between anterior and posterior mitral leaflets for localized fusion thereof, the delivery device comprising:
a capsule comprised of a first surface, a second surface, and at least one side surface, wherein the second surface is attached to an arm, wherein the first surface is opposite the second surface, and wherein the at least one side surface extending therebetween;
one or more capture features comprising and end portion and an attachment portion, wherein the end portion is configured for capturing the anterior and posterior mitral leaflets and wherein the attachment portion is connected to the capsule or the arm;
an applicator configured to apply the adhesive directly to the captured anterior and posterior mitral leaflets and coupled to the first surface of the capsule;
a cartridge in fluid communication with the applicator and containing the adhesive;
one or more energy elements located on the first surface of the capsule and configured to cure the applied adhesive;
a handle attached to the arm on an end opposite of the capsule comprising controls to actuate the one or more capture features, to apply the adhesive, and to activate the one or more energy elements; and
a delivery sheath extending along at least a portion of the arm and with dimensions to allow the capsule, one or more capture features, and applicator to retract therein.