R₂″ is phenyl, thiophenyl, benzthiophenyl, pyridinyl, naphthalenyl or indolyl, wherein any of which is/are optionally substituted by one-to-three substituents R₂₀, where each R₂₀ is independently selected from I, Br, Cl, F, and R₂₃, wherein R₂₃ is selected from OH, CN, NO₂, —C(O)—R_x, —O—C(O)—R_x, —S(O)—R_x, —S(O)₂—R_x, —CH₂—O—R_x, —NH—C(O)—R_x, and R₂₄, where R₂₄ is selected from linear- or branched-C₁-C₇-alkyl, C₃-C₁₀-cycloalkyl, C₃-C₁₀-cycloalkyl-linear- or branched-C₁-C₇-alkyl, linear- or branched-C₂-C₇-alkene, linear- or branched-C₂-C₇-alkyne, linear- or branched-C₁-C₇-alkoxy, linear- or branched-C₁-C₇-thioalkoxy, linear- or branched-C₂-C₇-alkenyloxy, linear- or branched-C₂-C₇-thioalkenyloxy, linear- or branched-C₂-C₇-alkynyloxy, linear- or branched-C₂-C₇-thioalkynyloxy, carbocyclic aryl, heteroaryl, heterocycloalkyl, and NH₂, wherein each R₂₄ may be substituted by one or two substituents independently selected from linear- or branched-C₁-C₇-alkyl, carbocyclic aryl, heteroaryl, carbocyclic aryl-linear- or branched-C₁-C₇-alkyl, heteroaryl-linear- or branched-C₁-C₇-alkyl, heterocycloalkyl or heterocycloalkyl-linear- or branched-C₁-C₇-alkyl, and wherein each R₂₃ is optionally substituted by one-to-four substituents independently selected from I, Br, Cl, F, and R₂₅, where R₂₅ is selected from OH, CN, NO₂, —C(O)—R_x, —O—C(O)—R_x, —S(O)—R_x, —O—S(O)—R_x,—CH₂—O—R_x, —NH—C(O)—R_x, and R₂₆, where R₂₆ is selected from linear- or branched-C₁-C₇-alkyl, C₃-C₁₀-cycloalkyl, C₃-C₁₀-cycloalkyl-linear- or branched-C₁-C₇-alkyl, linear- or branched-C₂-C₇-alkene, linear- or branched-C₂-C₇-alkyne, linear- or branched-C₁-C₇alkoxy, linear- or branched-C₁-C₇-thioalkoxy, linear- or branched-C₂-C₇-alkenyloxy, linear- or branched-C₂-C₇-thioalkenyloxy, linear- or branched-C₂-C₇-alkynyloxy, linear- or branched-C₂-C₇-thioalkynyloxy, carbocyclic aryl, heteroaryl, heterocycloalkyl, and NH₂, where each R₂₆ may be substituted by one or two substituents independently selected from linear- or branched-C₁-C₇-alkyl, carbocyclic aryl, heteroaryl, carbocyclic aryl- linear- or branched-C₁-C₇-alkyl, heteroaryl-linear- or branched-C₁ -C₇-alkyl,heterocycloalkyl or heterocycloalkyl- linear- or branched-C₁C₇-alkyl and wherein each R₂₅is optionally substituted by one-to-three substituents R₂₇ independently selected from I, Br, Cl, F and R₂₈, where R₂₈is selected from OH, CN, NO₂, —C(O)—R_x, —O—C(O)R_x, —S(O)—R_x, —O—S(O)—R_x, —CH₂—O—R_x, —NH—C(O)—R_x, linear- or branched-C₁-C₇-alkyl, C₃-C₁₀-cycloalkyl, C₃-C₁₀-cycloalkyl-linear- or branched-C₁-C₇-alkyl, linear- or branched-C₁-C₇-alkoxy, linear- or branched-C₁-C₇-thioalkoxy, carbocyclic aryl, heteroaryl, heterocycloalkyl, and NH₂, where each R₂₇ may be substituted by one or two substituents independently selected from linear- or branched-C₁-C₇-alkyl, carbocyclic aryl, heteroaryl, carbocyclic aryl- linear- or branched-C₁-C₇-alkyl, heteroaryl-linear- or branched-C₁-C₇-alkyl, heterocycloalkyl and heterocycloalkyl linear- or branched-C₁-C₇-alkyl;

R_x is OH, linear- or branched-C₁-C₇-alkoxy, linear- or branched-C₁-C₇-thioalkoxy, carbocyclic aryloxy, heteroaryloxy, thio-carbocyclic aryloxy, thio-heteroaryloxy, carbocyclic aryl-linear- or branched-C₁-C₇-alkoxy, carbocyclic-aryl-linear- or branched C₁-C₇-thioalkoxy, heteroaryl-linear- or branched-C₁-C₇-alkoxy, heteroaryl-linear- or C₁-C₇-thioalkoxy, or NH₂, any of which may be substituted by one or two substituents independently selected from linear- or branched-C₁-C₇-alkyl, carbocyclic aryl, heteroaryl, carbocyclic aryl-linear- or branched-C₁-C₇-alkyl, heteroaryl -linear- or branched-C₁-C₇-alkyl, heterocycloalkyl and heterocycloalkyl -linear- or branched-C₁-C₇-alkyl;

carbocyclic aryl is a mono-, bi- or tricyclic aryl selected from phenyl, phenyl that is substituted by one, two or three substituents selected from linear- or branched-C₁-C₇-alkyl, linear- or branched-C₁-C₇-alkoxy, linear- or branched-C₁-C₇-thioalkoxy, phenyl, hydroxy, I, Br, Cl, F, cyano, trifluoromethyl, linear- or branched-C₂-C₇-alkylenedioxy; oxy-C₂-C₃-alkylene; 1- or 2-naphthyl; and 1- or 2-phenanthrenyl;

heterocycloalkyl is a mono- bi- or tricyclic moiety comprising from 3-to 18 ring atoms, wherein 1-to-3 ring atoms is/are independently selected from O, S and N, and the remaining ring atoms are carbon atoms, which ring(s) is/are saturated or comprise(s) one or more unsaturated alkenyl or alkynyl bonds; and

heteroaryl is a mono- or bicyclic heteroaryl selected from pyridyl, indolyl, quinoxalinyl, quinolinyl, isoquinolinyl, benzothienyl, benzofuranyl, benzopranyl, benzothiophenyl, benzothiopyranyl, furanyl, pyrrolyl, thiazolyl, oxazolyl, isoxazolyl, triazolyl, tetrazolyl, pyrazolyl, imidazolyl and thienyl.