| US 7,615,226 B2 | ||
| Method for producing vaccines containing a heat-treated mixture consisting of at least one antigen and of at least one adjuvant | ||
| Hans Loibner, Vienna (Austria); and Helmut Eckert, Oberwil (Switzerland) | ||
| Assigned to Dr. Hans Loibner, Vienna (Austria) | ||
| Appl. No. 10/220,298 PCT Filed Mar. 21, 2001, PCT No. PCT/AT01/00080 § 371(c)(1), (2), (4) Date Sep. 12, 2002, PCT Pub. No. WO01/70264, PCT Pub. Date Sep. 27, 2001. |
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| Claims priority of application No. A 472/2000 (AT), filed on Mar. 21, 2000. | ||
| Prior Publication US 2003/0143221 A1, Jul. 31, 2003 | ||
| Int. Cl. A61K 39/00 (2006.01) | ||
| U.S. Cl. 424—184.1 [424/201.01; 424/278.1] | 12 Claims |
| 1. An immunogenically active vaccine formulation comprising a mixture formed by at least one antigen and at least one adjuvant,
said mixture having been subjected to a heat treatment at a temperature of from 100° C. to 125° C. for a period of time of
at least 5 minutes, said at least one antigen thereby having an improved adhesion on said at least one adjuvant,
wherein the antigen is a polypeptide and the adjuvant is an aluminum hydroxide.
|