US 7,612,240 B2
Halophospholanes and their preparation
Armin Börner, Rostock (Germany); Jens Holz, Kessin (Germany); Juan Almena, Hanau (Germany); Renat Kadyrov, Frankfurt (Germany); Axel Monsees, Frankfurt (Germany); and Thomas Riermeier, Ober-Ramstadt (Germany)
Assigned to Evonik Degussa GmbH, Essen (Germany)
Appl. No. 12/91,410
PCT Filed Oct. 04, 2006, PCT No. PCT/EP2006/067050
§ 371(c)(1), (2), (4) Date Apr. 24, 2008,
PCT Pub. No. WO2007/051679, PCT Pub. Date May 10, 2007.
Claims priority of application No. 10 2005 053 079 (DE), filed on Nov. 04, 2005.
Prior Publication US 2008/0287713 A1, Nov. 20, 2008
Int. Cl. C07F 9/02 (2006.01)
U.S. Cl. 568—12 7 Claims
 
1. Process for preparing compounds of the formula (I)

OG Complex Work Unit Drawing
in which
* is a stereogenic center,
X is Cl, Br, or I,
R1 and R4 are each independently (C1-C8)-alkyl, (C1-C8)-alkoxy, HO—(C1-C8)-alkyl, (C2-C8)-alkoxyalkyl,(C6-C18)-aryl, (C7-C19)-aralkyl, (C3-C18)-heteroaryl, (C4-C19)-heteroaralkyl, (C1-C8)-alkyl-(C6-C18)-aryl, (C1-C8)-alkyl-(C3-C18)-heteroaryl, (C3-C8)-cycloalkyl, (C1-C8)-alkyl-(C3-C8)-cycloalkyl, or (C3-C8)-cycloalkyl-(C1-C8)-alkyl,
R2, R3 are each independently R1, OH or H, or
(a)
R1 and R2 form a (C3-C5)-alkylene bridge together,
(b) R2 and R3 form a (C3-C5)-alkylene bridge together,
(c) R1 and R3 form a (C3-C5)-alkylene bridge together, or
(d) R2 and R4 form a (C3-C5)-alkylene bridge together,
wherein
compounds of the formula (II)

OG Complex Work Unit Drawing
in which
*, R1, R2, R3, R4 are each as defined above,
R, R′, R″ may each independently be R1,
are reacted with halogenated compounds selected from the group consisting of halocarbon compounds which lack double bonds in which the ratio of carbon atoms to halogen atoms is 1:≧2.5, CCl3CN, CCl3COOEt, CCl(3-x)HxC(═O)Cl, C2Cl4Br2, Cl2, Br2, I2.