US 7,612,202 B2
Process for preparing temozolomide
Olga Etlin, Beer-Sheva (Israel); Mohammed Alnabari, Hura (Israel); Yana Sery, Beer-Sheva (Israel); Edna Danon, Meitar (Israel); Oded Arad, Rechovot (Israel); and Joseph Kaspi, Givatayim (Israel)
Assigned to Chemagis, Ltd., Bnei Brak (Israel)
Filed on Feb. 16, 2006, as Appl. No. 11/354,899.
Claims priority of provisional application 60/735828, filed on Nov. 14, 2005.
Claims priority of provisional application 60/653528, filed on Feb. 17, 2005.
Prior Publication US 2006/0183898 A1, Aug. 17, 2006
Int. Cl. C07D 487/04 (2006.01); A61K 31/395 (2006.01); A61P 35/00 (2006.01)
U.S. Cl. 544—179 26 Claims
 
1. A process for preparing Temozolomide base, the process comprising:
contacting Temozolomide hydrochloride with at least one organic acid to produce Temozolomide base; and
isolating the Temozolomide base.