US 7,608,730 B2
Process for the preparation of an anti-tumor platinum (II)—complex
Golak Chandra Maikap, Ghaziabad (India); Bhagat Raj, Ghaziabad (India); Pradipta Kumar, Ghaziabad (India); Kannan Vivekanandan, Ghaziabad (India); and Chandrakant Belwal, Ghaziabad (India)
Assigned to Fresenius Kabi Oncology Limited, New Delhi (India)
Appl. No. 10/588,397
PCT Filed Feb. 05, 2004, PCT No. PCT/IN2004/000035
§ 371(c)(1), (2), (4) Date Mar. 26, 2008,
PCT Pub. No. WO2005/075489, PCT Pub. Date Aug. 18, 2005.
Prior Publication US 2008/0207935 A1, Aug. 28, 2008
Int. Cl. C07F 15/00 (2006.01)
U.S. Cl. 556—137 19 Claims
 
1. A process for the preparation of a platinum (II) complex compound of general formula (I)

OG Complex Work Unit Drawing
wherein the conformation of 1,2-diaminocyclohexane is cis, trans-(l) or trans-(d) isomer and R1 and R2 combinedly make dicarboxylic acid anion having formulae II, III and IV

OG Complex Work Unit Drawing
wherein n is zero or an integer ranging from 1 to 5 and R3 is H, alkoxy, halo or a nitro group comprising the steps of:
i) reacting a compound of formula M2PtX4 wherein X represents thiocyanate or a halogen atom selected from Cl, Br, and I with 1,2-diaminocyclohexane to give a compound of formula (V);

OG Complex Work Unit Drawing
ii) reacting the compound of formula (V) of step i), with a source of silver ion selected from a silver compound containing divalent anion in presence of an aliphatic carboxylic acid or an aliphatic or aromatic sulphonic acid to give compound of formula (VI)

OG Complex Work Unit Drawing
wherein R is —O—CO—R′ or O—SO2—R′, wherein R′ is H, an alkyl or an aryl group; and
iii) reacting the compound of formula (VI) of step ii), with a dicarboxylic acid or its salts to give the object platinum (II) complex compound of formula (I).