| US 7,603,172 B2 | ||
| System and method of using regression models to estimate vulnerable periods for heart stimulation parameters | ||
| Jie Lian, Beaverton, Oreg. (US); Dirk Muessig, West Linn, Oreg. (US); and Volker Lang, West Linn, Oreg. (US) | ||
| Assigned to Biotronik CRM Patent AG, Baar (Switzerland) | ||
| Filed on Nov. 15, 2006, as Appl. No. 11/560,141. | ||
| Prior Publication US 2008/0114411 A1, May 15, 2008 | ||
| Int. Cl. A61N 1/362 (2006.01) | ||
| U.S. Cl. 607—14 [607/9; 607/15; 607/17; 607/25] | 20 Claims |

| 1. A heart stimulator for stimulating at least a ventricle of a heart comprising:
a stimulation pulse generator adapted to generate electric stimulation pulses and connected or connectable to at least a ventricular
stimulation electrode configured to deliver electric stimulation pulses to at least said ventricle of said heart;
a sensing stage connected or connectable to an electrode configured to pick up electric potentials inside at least said ventricle
of said heart, said sensing stage adapted to sense an excitation or a contraction of a heart chamber;
a control unit, which is connected to said sensing stage and to said stimulation pulse generator and which is adapted to trigger
said stimulation pulse generator in a safe anti-tachycardia pacing time zone before a start or after an end of a vulnerable
period in a heart cycle and prior to an expected intrinsic excitation of said heart chamber to be stimulated when said heart
stimulator is in an anti-tachycardia pacing mode of operation;
memory connected to said control unit that contains patient specific data that characterizes a time relation between an intrinsic
heart rate as characterized by an RR-interval and a QT-interval characterized by a time period from a beginning of the heart
cycle to an end of the vulnerable period in that heart cycle wherein said patient specific data comprises an RT-RR or a QT-RR
regression model to estimate the vulnerable period at high heart rates where no corresponding RT-RR or QT-RR calibration data
exists at said high heart rates; and,
wherein said control unit is adapted to calculate an RVp interval based on a patient specific relation of a heart rate and
said QT-interval such that a stimulation pulse is triggered shortly before said start or after said end of said vulnerable
period for an actual heart rate.
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