| US 7,603,167 B2 | ||
| Method and apparatus for 3-D imaging of internal light sources | ||
| Daniel G. Stearns, Mountain View, Calif. (US); Bradley W. Rice, Danville, Calif. (US); and Michael D. Cable, Danville, Calif. (US) | ||
| Assigned to Xenogen Corporation, Alameda, Calif. (US) | ||
| Filed on Jul. 29, 2007, as Appl. No. 11/829,919. | ||
| Application 11/829919 is a continuation of application No. 10/606976, filed on Jun. 25, 2003. | ||
| Claims priority of provisional application 60/395357, filed on Jul. 16, 2002. | ||
| Claims priority of provisional application 60/396458, filed on Jul. 16, 2002. | ||
| Claims priority of provisional application 60/396313, filed on Jul. 16, 2002. | ||
| Prior Publication US 2008/0018899 A1, Jan. 24, 2008 | ||
| This patent is subject to a terminal disclaimer. | ||
| Int. Cl. A61B 6/03 (2006.01); A61B 6/12 (2006.01) | ||
| U.S. Cl. 600—473 [600/407; 600/425; 600/431; 600/438; 600/476; 250/363.01] | 19 Claims |
| 1. A method for obtaining a tree-dimensional representation of a light source distribution located inside a mammal, the method
comprising:
capturing surface light image data for light emitted from a surface portion of a mammal and propagating from the light source
distribution located inside the mammal to the surface portion;
obtaining a topographical surface representation of at least a portion of the mammal;
dividing the topographical surface representation into a set of surface elements;
creating a set of volume elements within the mammal, said set of volume elements relating to said set of surface elements;
converting the surface light image data into photon density just inside the surface of the mammal using the set of surface
elements and the set of volume elements; and
constructing a three-dimensional representation of the light source distribution internal to the mammal with a processor using
the photon density just inside the surface.
|