| US 7,601,846 B2 | ||
| Compounds having activity as inhibitors of apoptosis | ||
| Howard B. Cottam, Escondido, Calif. (US); Dennis A. Carson, La Jolla, Calif. (US); and Sylvie Barchechath, Geneva (Switzerland) | ||
| Assigned to The Regents of the University of California, Oakland, Calif. (US) | ||
| Filed on Nov. 10, 2005, as Appl. No. 11/271,511. | ||
| Application 11/271511 is a continuation in part of application No. 11/077986, filed on Mar. 11, 2005, abandoned. | ||
| Application 11/077986 is a continuation of application No. 10/364663, filed on Feb. 11, 2003, abandoned. | ||
| Application 10/364663 is a continuation of application No. PCT/US01/25175, filed on Aug. 10, 2001. | ||
| Claims priority of provisional application 60/301340, filed on Jun. 26, 2001. | ||
| Prior Publication US 2006/0122178 A1, Jun. 08, 2006 | ||
| Int. Cl. C07D 513/04 (2006.01); A61K 31/429 (2006.01) | ||
| U.S. Cl. 548—151 [544/133; 546/199; 514/233.2; 514/322; 514/366] | 4 Claims |
1. A compound of formula (IA):
 wherein R3 is hydrogen, halo, hydroxy, cyano, —N(Ra)(Rb), —S(Ra), —NO2, (C1-C6)alkyl, (C1-C6)alkoxy, (C2-C6)alkynyl, (C2-C6)alkenyl, (C2-C7)alkanoyl, (C2-C7)alkanoyloxy, or (C3-C7)cycloalkyl, wherein Ra and Rb are each independently hydrogen, (C1-C3)alkyl, (C2-C4)alkanoyl, phenyl, benzyl, or phenethyl; or Ra and Rb together with the nitrogen to which they are attached are a 5-6 membered heterocyclic ring;
wherein R4 is —N(Ra)(Rb) and wherein the —N(Ra)(Rb) of R4 is a 5-6 membered heterocyclic ring, optionally comprising 1, 2, or 3 N(Ra), non-peroxide O or S atoms;
Y is —S(O)0-2; n is 1, 2, 3, 4, or 5; or
a pharmaceutically acceptable salt thereof.
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