| US 7,601,841 B2 | ||
| Quinolinyl and benzothiazolyl modulators | ||
| Lawrence R. McGee, Pacifica, Calif. (US); Steven M. Rubenstein, Pacifica, Calif. (US); Atsushi Hagiwara, Osaka (Japan); Noboru Furukawa, Osaka (Japan); and Hisashi Shinkai, Osaka (Japan) | ||
| Assigned to Amgen Inc., Thousand Oaks, Calif. (US); and Japan Tobacco, Inc., Osaka (Japan) | ||
| Filed on Nov. 20, 2003, as Appl. No. 10/719,997. | ||
| Application 10/719997 is a continuation of application No. 10/278851, filed on Oct. 21, 2002, abandoned. | ||
| Application 10/278851 is a continuation of application No. 09/894980, filed on Jun. 27, 2001, granted, now 6,583,157. | ||
| Claims priority of provisional application 60/214810, filed on Jun. 28, 2000. | ||
| Prior Publication US 2004/0176409 A1, Sep. 09, 2004 | ||
| Int. Cl. C07D 215/38 (2006.01); A61K 31/501 (2006.01); A61K 31/47 (2006.01) | ||
| U.S. Cl. 546—153 [546/159; 546/160; 546/161; 514/252.04; 514/311; 514/312] | 22 Claims |
1. A compound having the formula:
 A is Cl or CF3;
C is Cl or CF3;
D is H or CH3;
V is F or Cl;
X is a member selected from the group consisting of H, CH3, COOH, and CO2CH3; and
Y is a member selected from the group consisting of H, CO2H and CO2CH3;
or a pharmaceutically acceptable salt thereof.
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