US 7,601,766 B2
Carboxylic siloxanyl monomers with pendant polymerizable groups
Derek Schorzman, Elliott City, Md. (US); Jay Kunzler, Canandaigua, N.Y. (US); and Joseph Salamone, Boca Raton, Fla. (US)
Assigned to Bausch & Lomb Incorporated, Rochester, N.Y. (US)
Filed on Jun. 30, 2006, as Appl. No. 11/480,171.
Prior Publication US 2008/0004414 A1, Jan. 03, 2008
Int. Cl. G02B 1/04 (2006.01)
U.S. Cl. 523—106  [523/107; 526/269; 526/279; 526/303.1; 526/371.1; 526/319; 526/320; 526/321; 528/26; 623/5.11; 623/6.11; 623/6.35; 623/7; 623/23.66] 10 Claims
 
1. A biomedical device comprising a polymerized monomer mixture comprising (a) one or more monomers of the Formula I:

OG Complex Work Unit Drawing
wherein x and y each is at least 1, L can be the same or different and is selected from the group consisting of a bond, a straight or branched C1-C30 alkylene group, a C1-C30 fluoroalkylene group, a C1-C20 ester-containing group, an alkylene ether, cycloalkylene ether cycloalkenyl ether, arylene ether, arylalkylene ether, a polyether containing group, amide-containing group, amine-containing group, a substituted or unsubstituted C3-C30 cycloalkylene group, a substituted or unsubstituted C3-C30 cycloalkylalkylene group, a substituted or unsubstituted C3-C30 cycloalkenyl group, a substituted or unsubstituted C5-C30 arylene group, a substituted or unsubstituted C5-C30 arylalkylene group, a substituted or unsubstituted C5-C30 heteroarylene group, a substituted or unsubstituted C3-C30 heterocyclic ring, a substituted or unsubstituted C4-C30 heterocyclolalkylene group, a substituted or unsubstituted C6-C30 heteroarylalkylene group, a C5-C30 fluoroarylene group, or a hydroxyl substituted alkylene ether, and combinations thereof; X is H, one equivalent alkali metal, or ½ equivalent alkaline earth metal; R is independently hydrogen, a straight or branched C1-C30 alkyl group, a C1-C30 fluoroalkyl group, a C1-C20 ester-containing group, an alkyl ether, cycloalkyl ether, cycloalkenyl ether, aryl ether, arylalkyl ether, a polyether containing group, a substituted or unsubstituted C1-C30 alkoxy group, a substituted or unsubstituted C3-C30 cycloalkyl group, a substituted or unsubstituted C3-C30 cycloalkylalkyl group, a substituted or unsubstituted C3-C30 cycloalkenyl group, a substituted or unsubstituted C5-C30 aryl group, a substituted or unsubstituted C5-C30 arylalkyl group, a substituted or unsubstituted C5-C30 heteroaryl group, a substituted or unsubstituted C3-C30 heterocyclic ring, a substituted or unsubstituted C4-C30 heterocyclolalkyl group, a substituted or unsubstituted C6-C30 heteroarylalkyl group, fluorine, a C5-C30 fluoroaryl group, or a hydroxyl group; and V is independently a polymerizable ethylenically unsaturated organic radical; and (b) at least one second monomer, wherein the biomedical device is selected from the group consisting of a soft contact lens, hydrogel contact lens, intraocular lens and a corneal implant.