| US 7,601,737 B2 | ||
| Isotopically substituted proton pump inhibitors | ||
| Bernhard Kohl, Constance (Germany); Bernd Müller, Constance (Germany); Dieter Haag, Lausen (Germany); Wolfgang-Alexander Simon, Constance (Germany); Karl Zech, Constance (Germany); Michael David, Stockach (Germany); Oliver Von Richter, Constance (Germany); and Felix Huth, Constance (Germany) | ||
| Assigned to Nycomed GmbH, Constance (Germany) | ||
| Filed on Dec. 12, 2007, as Appl. No. 12/376. | ||
| Application 12/000376 is a continuation of application No. PCT/EP2006/064669, filed on Jul. 26, 2006. | ||
| Application PCT/EP2006/064669 is a continuation of application No. PCT/EP2006/064666, filed on Jul. 26, 2006. | ||
| Claims priority of application No. 05106868 (EP), filed on Jul. 26, 2005; and application No. 05106874 (EP), filed on Jul. 26, 2005. | ||
| Prior Publication US 2008/0146610 A1, Jun. 19, 2008 | ||
| Int. Cl. A61K 31/437 (2006.01); C07D 471/04 (2006.01) | ||
| U.S. Cl. 514—303 [546/118] | 21 Claims |
1. A compound of formula 10
 R10 is hydrogen, difluoromethoxy or 1-4C-alkoxy,
R20 is 1-4C-alkyl or 1-4C-alkoxy,
R30 is 1-4C-alkyl, 1-4C-alkoxy, 2,2,2-trifluoroethoxy or 2-8C-alkoxyalkoxy,
R40 is hydrogen or 1-4C-alkyl,
Z is N,
or a salt or enantiomer thereof,
wherein at least one hydrogen atom of R10, R20, R30, R40 or any combination of R10, R20, R30 and R40 is replaced by a deuterium
atom.
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