US 7,601,352 B1
	Monoclonal antibodies and antigen binding fragments thereof capable of binding TrkA and inhibiting the functional activation of TrkA
Michal M. Novak, Bratislava (Slovakia (Slovak Republic))
Assigned to Lay Line Genomics S.p.A., Rome (Italy)
Appl. No. 9/979,710 PCT Filed May 26, 2000, PCT No. PCT/IT00/00218 § 371(c)(1), (2), (4) Date Mar. 08, 2002, PCT Pub. No. WO00/73344, PCT Pub. Date Dec. 07, 2000.
Claims priority of application No. RM99A0333 (IT), filed on May 26, 1999.
Int. Cl. A61K 39/395 (2006.01); A61K 39/00 (2006.01)

U.S. Cl. 424—141.1  [424/142.1; 424/135.1; 424/136.1; 424/130.1; 530/388.1; 530/388.22]

12 Claims

1. A monoclonal antibody or antigen binding fragment thereof, wherein said antibody or antigen binding fragment thereof is able to bind TrkA, wherein said antibody or antigen binding fragment thereof inhibits the functional activation of TrkA, and wherein the variable region of the light chain of said antibody or antigen binding fragment comprises the sequence from aa. 23 to aa. 134 of SEQ ID NO: 2.